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- Home
- Repositories
  - The Registry of Methods and Tools for Evidence-Informed Decision Making
  - Methods and Tools for Organizational Change
  - Health Evidence™
  - Repository of Public Health Evidence Syntheses
- Training
  - Videos
  - Evidence-Informed Decision-Making Competence Measure
  - Learning Needs Assessment for Evidence-Informed Decision Making
  - Online Learning Modules
  - University-Certified Learning Module Program
  - Webinars
  - Workshops
  - Knowledge Broker Mentoring Program
    
    KB Mentoring Impact
  - Knowledge Broker Virtual Office Hours
- Tools
  - Evidence-Informed Decision Making in Public Health
  - 6S Search Pyramid
  - Anatomy of a Systematic Review
  - Rapid Review Guidebook
  - EvSyS: The Evidence Synthesis Selection Tool for Decision Makers
  - Algorithm for Classifying the Study Design of Primary Studies
  - Quality Assessment of Community Evidence (QACE) Tools
  - Resource Planning and Assessment (RPA) Tool
  - Assessing Applicability and Transferability of Evidence Tool (A&T Tool)
  - Core Competency Tool
  - Mental Health Resources for Healthcare Workers
- Rapid Evidence Service
- Impact
  - Evidence-Informed Decision Making Casebook
  - Impact of the Knowledge Broker Mentoring Program
  - Why It Matters
  - NCCMT Publications
  - User Stories
  - Outreach
  - KT Student Awards
- About Us
  - About the NCCMT
  - Our Funder
  - Our Host Institution
  - The National Collaborating Centres
  - Team Members
  - Advisory Group Members
  - Students
  - COVID-19 Evidence Network to support Decision-making (COVID-END)
  - Contact Us

Vaccines in persons with a prior infection

Rapid Review Update 1: What is the ongoing effectiveness, immunogenicity, and safety of COVID-19 vaccines in persons who have had a prior, confirmed COVID-19 infection?

Vaccination in individuals with previous COVID-19 infection may be slightly more effective compared to those without previous infection, although the number of breakthrough infections was low in both groups.

Citation:

National Collaborating Centre for Methods and Tools. (2021, October 15). Rapid Review Update 1: What is the effectiveness, immunogenicity, and safety of COVID-19 vaccines in persons who have had a prior, confirmed COVID-19 infection? https://www.nccmt.ca/covid-19/covid-19-rapid-evidence-service/36

Public health topic area:

Disease Characteristics

Review question:

Population

Persons (any age) who had a prior, confirmed COVID-19 infection or are seropositive at the baseline of the study

Intervention

COVID-19 vaccines which Canada has currently authorized for use (AstraZeneca, Janssen/J&J, Moderna, Pfizer/BioNTech)

Comparisons

a) COVID-19 vaccination in persons without a previous confirmed SARS-CoV-2 infection or, persons with seronegative status at baseline; b) Unvaccinated persons with a previous confirmed COVID-19 infection

Outcomes

Effectiveness: Confirmed COVID-19 infection (PCR or serologic), asymptomatic or symptomatic, Hospitalizations due to COVID-19, ICU admissions due to COVID-19, Deaths due to COVID-19; Immunogenicity: Humoral immune responses (e.g., binding antibodies, neutralizing antibodies), Cellular immune responses (e.g., B cells, CD4+ and CD8+ T-cells, and associated cytokine responses); Safety: Local reactions due to vaccine, Systemic reactions due to vaccine, Serious adverse events due to vaccine

Search Updated:

Oct 6, 2021

Review Completed:

Oct 15, 2021

Previous versions:

Version 1

Jun 25, 2021

Current Version #2 Access the review

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