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McMaster
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Severe COVID-19 risk factors in children ages 0-5

Rapid Review: What are the risk factors associated with severe COVID-19 outcomes in children 5 years and under?
The findings of this review indicate that prematurity, young age, comorbidities, and structural inequities are the greatest risk factors for severe outcomes in children five years and younger.
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Severe COVID-19 risk factors in children ages 0-12

Rapid Review Update 1: What are the risk factors associated with severe COVID-19 outcomes in children 12 years and under?
The evidence suggests children with comorbidities may be more likely to experience severe COVID-19 outcomes.
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Vaccines in persons with a prior infection

Rapid Review Update 1: What is the ongoing effectiveness, immunogenicity, and safety of COVID-19 vaccines in persons who have had a prior, confirmed COVID-19 infection?
Vaccination in individuals with previous COVID-19 infection may be slightly more effective compared to those without previous infection, although the number of breakthrough infections was low in both groups.
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Surface transmission

Rapid Review Update 1: What is known about how long the virus can survive with potential for infection on surfaces found in community settings?
Viral fragments can be detected on surfaces but these fragments may not be viable to results in transmission.
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Re-infection

Rapid Review Update 3: What is known on the potential for COVID-19 re-infection, including new transmission after recovery?
Most syntheses and studies included in this review find no evidence of COVID-19 re-infection.
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Incubation period

Rapid Review: What is known about the duration from exposure to symptoms or diagnosis for COVID-19?
Precise calculation of the incubation period was more feasible early in the pandemic, when cases were limited and a precise exposure time was known. With widespread community transmission, accurate identification of exposure is challenging.
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